Vesicular proteins exocytosed and subsequently retrieved by compensatory endocytosis are nonidentical
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چکیده
منابع مشابه
Products of endocytosis and autophagy are retrieved from axons by regulated retrograde organelle transport
Cellular homeostasis in neurons requires that the synthesis and anterograde axonal transport of protein and membrane be balanced by their degradation and retrograde transport. To address the nature and regulation of retrograde transport in cultured sympathetic neurons, I analyzed the behavior, composition, and ultrastructure of a class of large, phase-dense organelles whose movement has been sh...
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Neurotransmission relies on the calcium-triggered exocytic fusion of non-peptide neurotransmitter-containing small synaptic vesicles (SVs) with the presynaptic membrane at active zones (AZs) followed by compensatory endocytic retrieval of SV membranes. Here, we study the diffusional fate of newly exocytosed SV proteins in hippocampal neurons by high-resolution time-lapse imaging. Newly exocytos...
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ژورنال
عنوان ژورنال: Nature Neuroscience
سال: 2006
ISSN: 1097-6256,1546-1726
DOI: 10.1038/nn1739